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- Postdoctoral Research Fellow in Biophysical Sciences

Description
Current Biophysical Postdoctoral Opportunities at St. Jude Children’s Research Hospital
At St. Jude Children’s Research Hospital, we stand at the forefront of biomedical research, seamlessly bridging basic science with innovative treatments for catastrophic pediatric diseases.
We are seeking the next generation of talented biomedical scientists interested in training at our world-class research center. We provide an outstanding training environment with support customized for postdocs and a competitive salary starting at $72,500 a year. Current biophysical postdoc opportunities are outlined below. Please visit www.stjude.org/postdoc for additional details. Our applicant-friendly process allows multiple faculty members to view your CV – simply email your CV to postdoc@stjude.org and indicate your interest in one or more of these exciting opportunities.
Scott Blanchard, PhD, Department of Structural Biology
Investigate the structural dynamics of GPCRs and their signaling partners using biophysical methods, including single-molecule FRET (smFRET).
Taosheng Chen, PhD, Department of Chemical Biology and Therapeutics
Study the regulation of nuclear receptors like PXR and CAR or enzymes like CYP3A4 and CYP3A5 by developing or characterizing novel chemical probes (i.e., small-molecule inhibitors or degraders).
Marcus Fischer, PhD, Department of Chemical Biology and Therapeutics
Reveal hidden factors contributing to protein dynamics, hydration, and protein-ligand binding from experimental and computational data, and leverage this information for ligand discovery.
Tanja Mittag, PhD, Department of Structural Biology
Three projects to choose from – (1) Understand the role of stress granules in neurodegenerative diseases via a combination of in vitro biophysics experiments and approaches in cells to elucidate the mechanism of fibril formation in the presence of complex stress granules. (2) Understand the role of phase separation in transcription to address whether small complexes or condensates dominate transcriptional function. And (3) Understand the role of phase separation for overexpressed transcription factors in disease processes.
Madan Mohan, PhD, Department of Structural Biology
Work with virologists and structural biologists to integrate mutational information with protein-level features associated with human adaptation and antigenic change to predict what currently circulating animal influenza viruses are most likely to acquire mutations related to human infection and adaptation.
Junmin Peng, PhD, Department of Structural Biology
Utilize a range of biochemical and genetic technologies, with a focus on cutting-edge mass spectrometry-based proteomics and metabolomics, to investigate the pathogenesis of cancer and neurodegenerative diseases in human iPSC-derived organoids, mouse models, and clinical tissues.
Jiyang Yu, PhD, Department of Computational Biology
Develop computational and systems biology approaches to analyze spatial and single-cell omics data (e.g., scRNA-seq, scATAC-seq, single-cell proteomics) and conduct integrative analyses of multidimensional datasets within the context of basic immunology and cancer immunotherapy.
Stanislav Zakharenko, MD, PhD, Department of Developmental Neurobiology
Understand the behavior in mouse models with 22q11 and 3q29 deletion syndromes (that have high genetic risks of developing psychiatric disorders, especially schizophrenia) at the levels of neural circuits, individual neurons, synapses, and molecules by conducting 2-photon laser-scanning microscopy imaging of neuronal activity in awake mice.
Blue Sky Kinase Project, Department of Structural Biology
Actively design and develop biochemical and biophysical assays to support small molecule hit identification and MOA studies for kinases and help characterize the identified inhibitors using biochemical, biophysical, and cellular tools.
About St. Jude
St. Jude Children's Research Hospital, located in Memphis, Tennessee, is one of the world's premier research and treatment centers for pediatric cancer and catastrophic childhood diseases. Scientists and clinicians work together daily to translate laboratory discoveries into clinical trials and new therapies for patients. The environment at St. Jude is highly interactive, with opportunities to collaborate with investigators across the campus. All investigators have access to state-of-the-art core facilities, including structural biology cores, proteomics, gene editing, bioinformatics, imaging, protein production, molecular synthesis, and high-throughput small molecule screening.
St. Jude is an Equal Opportunity Employer. St. Jude does not discriminate based on race, national origin, sex, genetic information, sexual orientation, age, religion, disability, veteran’s status, or disabled veteran’s status with respect to employment opportunities. All qualified applicants will be considered for employment. St. Jude engages in affirmative action to increase employment opportunities for minorities, women, veterans, and individuals with disabilities.